Upstream Bio

Upstream Bio

Biotechnology
Upstream Bio Inc is a clinical-stage biotechnology company developing treatments for inflammatory diseases, with an initial focus on severe respiratory disorders. It is developing verekitug, the known antagonist currently in clinical development that targets the receptor for Thymic Stromal Lymphopoietin (TSLP), a cytokine that is a clinically validated driver of inflammatory response positioned upstream of multiple signaling cascades that affect a variety of immune-mediated diseases.

$292.5M

Market Cap • 9/18/2026

2021

(5 years)

Founded

2024

(2 years ago)

IPO

NASDAQ

Listing Exchange

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United States

Country

Valuation

P/B

1,1

P/S

92,6

P/EBITDA

P/OCF

P/FCF

P/E

BVPS

5

EPS

Market Cap

Market Cap

292,5M

EV

32,1M

EV/Revenue

10,2

EV/EBITDA

-0,2

EV/EBIT

-0,2

Payout

Dividend Per Share

0

Dividend Yield

0%

Buyback Yield

-1,7%

Total Yield

-1,7%

Payout

0%

Retained Earnings

-414,5M

Profitability

Gross Margin

100%

EBITDA Margin

EBIT Margin

Net Margin

D&A/EBITDA

0%

R&D/Revenue

4616,8%

Capex/Revenue

0%

Capex/D&A

0%

Capex/OCF

0%

SBC/OCF

% PPE

0,5%

% Goodwill

0%

ROE

ROIC

Leverage

N.D./EBITDA

1,5

Debt/Equity

0%

Current Ratio

28

Quick Ratio

26,2

Interest Coverage

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